连续微反应加氢技术在有机合成中的研究进展

加氢反应是有机合成中很常见的一种反应类型，采用常规的间歇加氢釜具有反应效率低、操作烦琐和安全性差等问题。而连续加氢微反应器进行非均相催化加氢反应能提供更高的传质性能，催化剂的回收利用与产物的纯化也更为方便，能极大地提高生产效率，减少贵金属催化剂的损失。因为这些优点，连续微反应加氢技术得到了越来越多的关注。本文阐述了连续微反应加氢技术中常用的微反应器与固体金属催化剂类型，以及不同官能团非均相高效催化加氢的研究进展，在此基础，对该技术在精细化工领域的应用进行了展望。连续微反应加氢技术使得加氢过程可以在更安全、更高效、更环保的条件下完成，具有很高的工业应用价值，是未来化学化工领域重点发展的方向之一。

Research progress of continuous hydrogenation in organic synthesis

The hydrogenation reaction is a type of reaction which is very common in organic synthesis. The conventional batch hydrogenation reactor has the problems of low reaction efficiency, cumbersome operation and poor safety. The method of heterogeneous hydrogenation in a continuous microreactor can provide higher mass transfer performance, easy recycling of the catalyst and the purification of the product are more convenient, which can greatly improve the production efficiency and reduce the loss of precious metal catalysts. With these advantages, continuous hydrogenation technology in microreactors has received more and more attention. The research progress of commonly used microreactors and solid metal catalyst types, as well as heterogeneous high-efficiency catalytic hydrogenation of different functional groups in continuous microreactor are described in this paper. On this basis, the application of this technology in the field of fine chemicals is prospected. The continuous microreactor technology enables the hydrogenation process under safer, more efficient and more environmentally friendly conditions. It has high industrial application value and is one of the key development directions in the chemical industry in the future.