| 静电纺制备的PLLA/PCL复合支架性能及细胞相容性 |
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| 引用本文： | 唐勇红,杨庆,岑莲,郯志清,沈新元.静电纺制备的PLLA/PCL复合支架性能及细胞相容性[J].高分子材料科学与工程,2010(9). |
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| 作者姓名： | 唐勇红 杨庆 岑莲 郯志清 沈新元 |
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| 作者单位： | 东华大学材料科学与工程学院;东华大学纤维材料改性国家重点实验室;上海组织工程研究与开发中心; |
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| 摘 要： | 利用静电纺丝技术制备了一系列不同比例的左旋聚乳酸/聚己内酯(PLLA/PCL)复合纳米纤维支架。通过扫描电镜、差热分析、宽角X射线衍射和接触角测试手段对支架结构与形态、结晶性能及亲水性进行了表征;采用在缓冲溶液中加酶的方式,研究了复合材料的降解性能;将体外培养的真皮成纤细胞接种至材料表面,用扫描电镜观察了成纤细胞在材料表面的生长情况。研究结果表明,电纺丝得到的复合支架纤维直径均一,且呈相互连通的多孔网状结构;脂肪酶的存在加速了支架材料的降解速度;成纤细胞在复合支架上具有良好的生长状态。
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| 关 键 词： | 静电纺丝 组织工程 复合支架 酶降解 |
Performance and Cell-Compatibility of PLLA/PCL Composite Scaffolds Prepared by Electrospinning |
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| TANG Yong-hong,YANG Qing,CEN Lian,TAN Zhi-qing,SHEN Xin-yuan.Performance and Cell-Compatibility of PLLA/PCL Composite Scaffolds Prepared by Electrospinning[J].Polymer Materials Science & Engineering,2010(9). |
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| Authors: | TANG Yong-hong YANG Qing CEN Lian TAN Zhi-qing SHEN Xin-yuan |
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| Affiliation: | TANG Yong-hong1,YANG Qing1,2,CEN Lian3,TAN Zhi-qing1,SHEN Xin-yuan1,2(1. College of Material Science and Engineering,Donghua University,2. State Key Laboratory for Modification of Fiber Materials,Shanghai 201620,China,3. Center of Research and Development for Tissue Engineering,Shanghai 200235,China) |
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| Abstract: | A series of ultra-fine poly-L-lactide/polycaprolactone(PLLA/PCL) composite nanofibers were prepared via electrospinning technique. The structure,morphology,crystallization property and hydrophilicity of the electrospun fibers were characterized by scanning electron microscopy,thermal analysis,wide angle X-ray diffraction and contact angle. Degradation behaviors were investigated in phosphate solution(PBS) aqueous with the present of lipase. Dermal fibroblasts were seeded on electrospun scaffolds and the cel... |
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| Keywords: | electrospinning tissue engineering composite scaffolds enzymatic degradation |
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