| 氢化铝锂还原多取代嘧啶氰基 |
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| 引用本文： | 余申义,佟太锋,魏朝俊,李明磊. 氢化铝锂还原多取代嘧啶氰基[J]. 化学试剂, 2006, 28(6): 357-358,368 |
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| 作者姓名： | 余申义 佟太锋 魏朝俊 李明磊 |
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| 作者单位： | 北京化工大学,理学院,北京,100029;北京化工大学,理学院,北京,100029;北京化工大学,理学院,北京,100029;北京化工大学,理学院,北京,100029 |
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| 摘 要： | 以丙二腈为起始原料,合成了2个5-氰基-4-氨基-2,6-二烷硫基嘧啶,然后以氢化铝锂做还原剂,经过对溶剂、还原剂用量等实验条件的初步筛选,结果在四氢呋喃溶剂中,采用底物与氢化铝锂1∶4的物质的量比,以80%~85%的产率得到2个5-氨甲基-4-氨基-2,6-二烷硫基嘧啶化合物。底物和产物4个结构均经IR1、HNMR和元素分析确证。
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| 关 键 词： | 氢化铝锂 氰基还原 多取代嘧啶 |
| 文章编号： | 0258-3283（2006）06-0357-02 |
| 收稿时间： | 2005-09-30 |
| 修稿时间： | 2005-09-30 |
Reducing cyano-group of polysubstituted pyrimidines with tetrahydroaluminlithium |
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| YU Shen-yi,TONG Tai-feng,WEI Chao-jun,LI Ming-lei. Reducing cyano-group of polysubstituted pyrimidines with tetrahydroaluminlithium[J]. Chemical Reagents, 2006, 28(6): 357-358,368 |
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| Authors: | YU Shen-yi TONG Tai-feng WEI Chao-jun LI Ming-lei |
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| Affiliation: | College of Science, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | Two kinds of 4-amino-5-eyano-2, 6-dialkylthiopyrimidine were synthesized from malanonitrile, and then reduced with LiAIH4 in THF to two 4-amino-5-aminomethyl-2,6-dialkylthiopyrimidines with a yield of 80 % - 85 %. The structures of them were characterized by IR, ^1HNMR spectra and elemental analysis. |
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| Keywords: | tetrahydroaluminlithium reduction polysubstituted pyrimidine cyano-group |
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