| 牛血清白蛋白与三唑酮结合作用的热力学研究 |
| |
| 引用本文： | 童金强,熊泽云,张华,梅平. 牛血清白蛋白与三唑酮结合作用的热力学研究[J]. 化学与生物工程, 2008, 25(12) |
| |
| 作者姓名： | 童金强 熊泽云 张华 梅平 |
| |
| 作者单位： | 长江大学化学与环境工程学院,湖北,荆州,434023;荆楚理工学院化学与药学院,湖北,荆门,448000 |
| |
| 摘 要： | 在模拟人体生理条件下,采用分子光谱法研究了三唑酮与牛血清白蛋白的相互作用.结果发现,三唑酮对牛血清白蛋白的内源荧光有一定的猝灭作用,由Stern-Volmer方程和Van't Hoff等压方程分析处理实验数据,得到了结合作用的平衡常数,结合反应的热力学参数、结合作用力类型等.
|
| 关 键 词： | 三畦酮 牛血清白蛋白 荧光光谱法 热力学参数 |
Thermodynamic Studies on the Binding Interaction Between Tradimefon and Bovine Serum Albumin |
| |
| TONG Jin-qiang,XIONG Ze-yun,ZHANG Hua-xin,MEI Ping. Thermodynamic Studies on the Binding Interaction Between Tradimefon and Bovine Serum Albumin[J]. Chemistry & Bioengineering, 2008, 25(12) |
| |
| Authors: | TONG Jin-qiang XIONG Ze-yun ZHANG Hua-xin MEI Ping |
| |
| Affiliation: | TONG Jin-qiang1,XIONG Ze-yun2,ZHANG Hua-xin2,MEI Ping1 (1.College of Chemical , Environmental Engineering,Yangtze University,Jingzhou 434023,China,2.College of Chemical , Pharmaceutical Engineering,Jingchu University of Technology,Jingmen 448000,China) |
| |
| Abstract: | The interaction of tradimefon to bovine serum albumin(BSA) was studied using molecular spectroscopy by imitating human body physiology environment.The result showed that this compound had a powerful ability to quench the BSA fluorescence.By analyzing the spectral data with Stern-Volmer equation and Van't Hoff equation,the static fluorescence quenching binding constant,the thermodynamic parameters,and the binding power were obtained. |
| |
| Keywords: | tradimefon bovine serum albumin fluorescence spectrum thermodynamic parameter |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
