Synthesis and study of antimicrobial activity of bioconjugates of silver nanoparticles and endogenous antibiotics |
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Authors: | O Yu Golubeva O V Shamova D S Orlov T Yu Pazina A S Boldina I A Drozdova V N Kokryakov |
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Affiliation: | 1.Grebenshchikov Institute of Silicate Chemistry,Russian Academy of Sciences,St. Petersburg,Russia;2.Institute of Experimental Medicine, North-Western Branch,Russian Academy of Medical Sciences,St. Petersburg,Russia |
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Abstract: | Bioconjugates of silver nanoparticles and antimicrobial peptides of the bactenecin family, which are endogenous antibiotics,
have been synthesized. The biological activity of the prepared bioconjugates has been evaluated. It has been established that
the conjugates of silver nanoparticles with the peptide G-Bac3.4 exhibit an antimicrobial activity, including the activity
with respect to the strain Pseudomonas aeruginosa resistant to traditional antibiotics and the strain Staphylococcus aureus (MRSA ATCC 33591) resistant to methicillin. It has been demonstrated that the complexes of silver nanoparticles with antimicrobial
peptides do not possess a pronounced membranolytic effect inherent in peptides. The results obtained have made it possible
to draw the conclusion that the properties of the synthesized conjugates differ from those characteristic of constituting
peptides and silver nanoparticles. |
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