| 氧化法合成3,5-吡啶二甲酸 |
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| 引用本文： | 叶超,卢丹,倪生良.氧化法合成3,5-吡啶二甲酸[J].内蒙古石油化工,2011,37(1):1-2. |
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| 作者姓名： | 叶超 卢丹 倪生良 |
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| 作者单位： | 湖州师范学院生命科学学院,浙江,湖州,313000 |
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| 基金项目： | 湖州师范学院第八届大学生科研项目(2010-78) |
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| 摘 要： | 目的:改进3,5-吡啶二甲酸的合成工艺。方法:以3,5-二甲基吡啶为原料,采用KMnO4在相转移催化剂的存在下搅拌和回流氧化3,5-二甲基吡啶合成3,5-吡啶二甲酸,经抽滤除二氧化锰,再减压蒸馏、酸化、沉淀、抽滤、洗涤、干燥、重结晶得到白色晶体,最后对白色晶体进行表征,与标准物质进行比较。结果:最佳反应条件:高锰酸钾对3,5-二甲基吡啶2.2倍过量,反应120min,反应温度100℃,相转移催化剂用量为6%条件下,氧化反应得率为42%。
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| 关 键 词： | 3 5-二甲基吡啶 3 5-吡啶二甲酸 相转移催化剂 合成 |
Preparation of 3,5-pyridinedicarboxylic acid with oxidation |
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| YE Chao,LU Dan,NI Sheng-liang.Preparation of 3,5-pyridinedicarboxylic acid with oxidation[J].Inner Mongulia Petrochemical Industry,2011,37(1):1-2. |
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| Authors: | YE Chao LU Dan NI Sheng-liang |
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| Affiliation: | YE Chao,LU Dan,NI Sheng-liang(School of Life Science,Huzhou Teachers College,Huzhou 313000) |
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| Abstract: | Object:To improve the synthesis of 3,5-pyridine dicarboxylic acid.Methods:3,5-pyridine dicarboxylic acid was synthesized from 3,5-dimethylpyridine.We executive the reaction of oxidation with KMnO4 in the phase transfer catalyst under stirring condition by reflux heating,then remove MnO2 by decompress filter,vacuum distilled,acidify,precipitate,dry,purity and obtain a white crystalized powder.Finally,the white crystalized powder's structure has been characterized and compared with the target compound.Conclus... |
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| Keywords: | 3 5-Dimethyl Pyridine 5-Pyridine Dicarboxylic Acid Phase Transfer Catalyst Synthesis |
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