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替米考星β-CDP载药微球的制备及释药性能研究
引用本文:杨黎燕,余丽丽,姚琳,尤静.替米考星β-CDP载药微球的制备及释药性能研究[J].化学与生物工程,2013,30(1):71-74.
作者姓名:杨黎燕  余丽丽  姚琳  尤静
作者单位:西安医学院药学院,陕西西安,710021
基金项目:陕西省卫生厅科研资助项目,陕西省教育厅科研计划资助项目,陕西省教育厅产业化项目
摘    要:采用共沉淀法制备了替米考星β-CDP载药微球,讨论了投药比、反应时间、反应温度对替米考星β-CDP载药微球的影响,并探讨了其体外释药情况,运用红外光谱仪、电镜、粒度分析仪对产物进行了表征。结果表明,在β-CDP微球质量为3g、替米考星质量为0.25g、反应温度为50℃、反应时间为1.0h、搅拌速度为400r·min^-1的条件下制得的载药微球的产率为81.60%、包封率为66.05%。替米考星β-CDP载药微球粒径分布均匀,外观圆整,在pH值为7.4的PBS中释药效果较好。载药微球释药与Korsmeyer—Peppas方程有较好拟合。

关 键 词:替米考星  β-环糊精聚合物  制备  体外释药

Study on Preparation and Drug Release of Tilmicosin β-Cyclodextrin Polymer Microspheres
YANG Li-yan , YU Li-li , YAO Lin , YOU Jing.Study on Preparation and Drug Release of Tilmicosin β-Cyclodextrin Polymer Microspheres[J].Chemistry & Bioengineering,2013,30(1):71-74.
Authors:YANG Li-yan  YU Li-li  YAO Lin  YOU Jing
Affiliation:(College of Pharmacy,Xi′an Medical University,Xi′an 710021,China)
Abstract:Tilmicosin β-cyclodextrin polymer (β-CDP) mierospheres was prepared by coprecipitation method. The influence of preparation conditions on tilrnicosin β-CDP microspheres and its drug release in vitro were investigated. Fourier transform infrared spectroscopy (IR),scanning electron microscopy (SEM) and granularity analyaer were used to character tilmicosin β-CDP. The results showed that the optimum prepa- ration conditions were as follows: the quantity of fl-CDP was 3 g, the quantity of tilmicosin was 0.25 g, the reaction temperature was 50 ℃,the reaction time was 1.0 h,the stirring speed was 400 r· min^-1. The yield and drug encapsulation rate were 81.60% and 66.05%, respectively under above conditions. The tilmicosin β-CDP microspheres was uniform in particle size distribution,was round in appearance,and had a good drug release in PBS(pH=7.4). And Korsmeyer-Peppas equation was adapted for its drug release characteristic.
Keywords:tilmicosin  β-cyelodextrin polymer  preparation  drug release in vitro
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