| 1-(4-氯苯基)-3-吡唑醇的合成 |
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| 引用本文： | 丁成荣,范杰,夏光华,项继聪,何胜利,张国富.1-(4-氯苯基)-3-吡唑醇的合成[J].农药,2011,50(5). |
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| 作者姓名： | 丁成荣 范杰 夏光华 项继聪 何胜利 张国富 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,杭州,310032 |
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| 基金项目： | 国家自然科学基金，浙江省教育厅科研计划项目，浙江省化学工程与新材料研究生教育创新示范基地 |
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| 摘 要： | 方法]1-(4-氯苯基)-3-吡唑醇是一种重要农药中间体,以对氯苯肼为原料经环合、氧化,合成1-(4-氯苯基)1-3-毗唑醇.结果]在优化的反应条件下,1-(4-氯苯基)-3-吡唑醇的反应总收率为72.5%(以对氯苯肼计),含量为99.2%,其结构经红外和氢谱核磁分析确证.结论]该工艺具有反应条件温和、产品收率高等优点,适合工业化生产.
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| 关 键 词： | 对氯苯肼 1-(4-氯苯基)-3-吡唑醇 合成 |
Synthesis of 1-(4-Chlorophenyl)-3-hydroxypyrazole |
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| DING Cheng-rong,FAN Jie,XIA Guang-hua,XIANG Ji-cong,HE Sheng-li,ZHANG Guo-fu.Synthesis of 1-(4-Chlorophenyl)-3-hydroxypyrazole[J].Pesticides,2011,50(5). |
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| Authors: | DING Cheng-rong FAN Jie XIA Guang-hua XIANG Ji-cong HE Sheng-li ZHANG Guo-fu |
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| Affiliation: | DING Cheng-rong,FAN Jie,XIA Guang-hua,XIANG Ji-cong,HE Sheng-li,ZHANG Guo-fu(College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou 310032,China) |
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| Abstract: | Methods]As an important intermediate of pesticides,1-(4-chlorophenyl)pyrazolidin-3-one could besynthesized by the cyclization and oxidation from the raw material 4-chlorophenylhydrazine.Results]Under the optimalcondition,the total yield was 72.5%based on 4-chlorophenylhydrazine and the purity was 99.2%.The structure of theresulting product was confirmed by IR and1H NMR.Conclusions]The process exhibited mild reaction conditions andhigh yield,and is suitable for industrial production. |
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| Keywords: | 4-chlorophenylhydrazine 1-(4-chlorophenyl)-3-hydroxypyrazole synthesis |
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