Metal-Organic Sheets for Efficient Drug Delivery and Bioimaging |
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| Authors: | Yucong Song Jingjie Yang Dr. Lei Wang Prof. Zhigang Xie |
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| Affiliation: | 1. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China University of Science and Technology of China, Hefei, 230026 China;2. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China |
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| Abstract: | Metal-organic frameworks (MOFs) formed by coordination between metal ions or clusters and organic bridging ligands possess great potential for biomedicine applications, given their high biocompatibility and biodegradability. Compared with the traditional three-dimensional (3D) MOFs, two-dimensional (2D) MOFs with sheet-like morphologies exhibit unique properties. In this study, a nanoscale 2D leaf-shaped MOF (NZIF−L) was synthesized via coordination self-assembly between 2-methylimidazole (Hmim) and Zn2+ with subsequent morphology and size control. The fabricated NZIF−L is cytocompatible and can be quickly endocytosed, which makes it an excellent cargo carrier. Subsequent to loading with either doxorubicin (DOX) or 4,4′-(1,2-diphenylvinyl)-1,2-di-(phenylcarboxylic acid) (TCPE), the respectively obtained DOX@NZIF−L and TCPE@NZIF−L showed promise for killing and imaging cancer cells. |
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| Keywords: | MOF sheets nanocarriers drug delivery bioimaging cancer therapy |
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