|
|||||
|
|
Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis |
|
| Authors: | Dr. Zhen Li Ying Peng Dr. Xiangchao Pang Dr. Bin Tang |
| Affiliation: | 1. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055 China Department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, 430072 China These authors contributed equally to this work;2. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055 China These authors contributed equally to this work;3. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055 China |
| Abstract: | This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and to broaden the application field of MOFs. Mg/HCOOH−MOF was introduced and characterized by using SEM, XRD, TGA, and FTIR. ICP-MS results proved that Mg/HCOOH−MOF is stable in various physiological media and can maintain the release of Mg2+ ions for a long time. In vitro experiments were carried out to evaluate its potential application in attenuating OA. Mg/HCOOH−MOF was successfully synthesized, and results of MTT assays showed that it is biocompatible and can promote cell proliferation. qPCR results suggested that it can significantly regulate the expression of OCN, Axin2, iNOS and IL-1β, which indicated its activity in anti-inflammation and bone protection. We believe that Mg/HCOOH−MOF could benefit OA therapy. |
| Keywords: | magnesium MOF bone protection anti-inflammation osteoarthritis |