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5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms |
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| Authors: | Bram H. Frohock Jessica M. Gilbertie Dr. Jennifer C. Daiker Dr. Lauren V. Schnabel Dr. Joshua G. Pierce |
| Affiliation: | 1. Department of Chemistry, College of Sciences, NC State University, 2620 Yarbrough Drive, Raleigh, NC, 27695 USA;2. Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607 USA;3. Department of Chemistry, College of Sciences, NC State University, 2620 Yarbrough Drive, Raleigh, NC, 27695 USA Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607 USA Comparative Medicine Institute, NC State University, Raleigh, NC, 27607 USA |
| Abstract: | The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative approaches to treatment so as to curtail the growing crisis. In addition to traditional resistance mechanisms resulting in the lack of efficacy of many antibiotics, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms. Herein, we report an expanded set of 5-benzylidene-4-oxazolidinones that are able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms, and, in combination with common antibiotics, are able to significantly reduce the bacterial load in a robust collagen-matrix model of biofilm infection. |
| Keywords: | antibiotic adjuvants antibiotics biofilm eradication natural products oxazolidinone |