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Zinc Deficiency Leads to Lipid Changes in Drosophila Brain Similar to Cognitive-Impairing Drugs: An Imaging Mass Spectrometry Study |
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| Authors: | Mai H. Philipsen Chaoyi Gu Prof. Andrew G. Ewing |
| Affiliation: | 1. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemigården 4, 412 96 Göteborg, Sweden These authors contributed equally to this work.;2. Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 4, 412 96 Göteborg, Sweden These authors contributed equally to this work.;3. Department of Chemistry and Molecular Biology, University of Gothenburg, Kemigården 4, 412 96 Göteborg, Sweden |
| Abstract: | Several diseases and disorders have been suggested to be associated with zinc deficiency, especially learning and memory impairment. To have better understanding about the connection between lipid changes and cognitive impairments, we investigated the effects of a zinc-chelated diet on certain brain lipids of Drosophila melanogaster by using time-of-flight secondary ion mass spectrometry (ToF-SIMS). The data revealed that there are increases in the levels of phosphatidylcholine and phosphatidylinositol in the central brains of the zinc-deficient flies compared to the control flies. In contrast, the abundance of phosphatidylethanolamine in the brains of the zinc-deficient flies is lower. These data are consistent with that of cognitive-diminishing drugs, thus providing insight into the biological and molecular effects of zinc deficiency on the major brain lipids and opening a new treatment target for cognitive deficit in zinc deficiency. |
| Keywords: | cognition Drosophila melanogaster lipid changes mass spectrometry imaging zinc deficiency |