Activity-Directed Synthesis: A Flexible Approach for Lead Generation |
| |
Authors: | Dr George Karageorgis Dr Samuel Liver Prof Adam Nelson |
| |
Affiliation: | 1. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT UK;2. School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT UK
Rosalind Franklin Institute, Harwell Campus, Didcot, OX11 0FA UK |
| |
Abstract: | Activity-directed synthesis (ADS) is a structure-blind, functional-driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses reactions with multiple possible outcomes, and allows many chemotypes to be evaluated in parallel. Resources are focused on bioactive molecules, which emerge in tandem with associated synthetic routes. Some of the future challenges for ADS are highlighted, including the realisation of an autonomous molecular discovery platform. The prospects for ADS to become a mainstream lead generation approach are discussed. |
| |
Keywords: | lead generation molecular diversity reaction toolkit |
|
|