| Affiliation: | 1. Federal University of Pará, Laboratory R&D Pharmaceutical and Cosmetic, College of Pharmacy, Avenida Artur Correia, 66075-110 Belém, Pará, Brazil;2. Federal University of Pará, Faculty of Food Engineering, Belém, Pará, Brazil;3. Federal University Pará, Institute of Biological Sciences, Laboratory of Structural Biology, Belém, Pará, Brazil National Institute of Science and Technology in Structural Biology and Bioimaging, Rio de Janeiro, Rio de Janeiro, Brazil;4. Federal University of Pará, Laboratory Pharmaceutical Nanotechnology, College of Pharmacy, Belém, Pará, Brazil |
| Abstract: | Nanoemulsion-based acai oil was obtained by the phase inversion method using two nonionic surfactants, Ceteareth-20 (Brij™ CS20) and polyoxyethylene-hydrogenated castor oil (Croduret™ 50), with the concentration of each surfactant varying from 7 to 10 %. The formulation with 10 % Brij CS20 presented the best values for droplet size, zeta potential, and polydispersity index (PDI). Ketoconazole was incorporated into this formulation, with an encapsulation efficiency of 98.31 % and equally good zeta potential, droplet size, and PDI, and spherical shape when observed by transmission electron microscopy. Overall, nanoemulsions of acai oil proved to be a good vehicle for imidazole antifungals such as ketoconazole. |
