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Acidity and Glutathione Dual-Responsive Polydopamine-Coated Organic-Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery |
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| Authors: | Qi Chen Yunna Chen Wenjing Zhang Qianqian Huang Mengru Hu Prof. Daiyin Peng Dr. Can Peng Dr. Lei Wang Prof. Weidong Chen |
| Affiliation: | 1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012 China These authors contributed equally to this work.;2. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012 China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui, 230012 China These authors contributed equally to this work.;3. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012 China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui, 230012 China;4. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012 China;5. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012 China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui, 230012 China Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, Anhui, 230012 China;6. College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012 China |
| Abstract: | Controversial biodegradability and nonspecific pre-drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic-inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultaneously achieve enhanced biodegradability and controllable drug release. The morphology and chemical structure of the nanoparticles were characterized by TEM, N2 adsorption-desorption isotherms, TEM-mapping and XPS. Moreover, the release behavior of nanoparticles under various pH conditions and the degradation behavior in the presence of GSH were evaluated. With effective controlled release, HMONs-PTX@PDA were shown to significantly inhibit cancer cell proliferation and achieve antitumor effects in vivo through dual-response release in the tumor microenvironment. Overall, this nanoplatform has significant potential to achieve tumor microenvironment-responsive degradation and release to enhance tumor accumulation, which is very promising for cancer treatment. |
| Keywords: | hollow mesoporous silica nanoparticles pH-sensitive GSH-responsive paclitaxel cancer treatment |