| 13C-甲醇的制备 |
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| 引用本文： | 罗勇,杜晓宁,宋家龙,陆平晔,李美华.13C-甲醇的制备[J].同位素,2012,25(4):214-218. |
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| 作者姓名： | 罗勇 杜晓宁 宋家龙 陆平晔 李美华 |
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| 作者单位： | 上海化工研究院，上海200062 |
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| 基金项目： | “十一五”国家科技支撑计划(2009BAK61B04);科技部转制院所专项(2011EG116066) |
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| 摘 要： | 采用自制的催化剂和自行设计的高效催化反应器，用催化加氢的方法，以Ba13CO3为原料制备了13C-甲醇。所得甲醇水溶液在微型高效精馏反应器中进一步提纯后，得到的13C-甲醇化学纯度＞99.5%。实验设计的合成路线反应条件温和，同位素利用率＞90%。13C-甲醇经色质联用（GC-MS）和核磁（1H NMR）检测，13C同位素丰度＞97%，13C-甲醇的同位素丰度与原料相比降低＜1%。以上结果表明，采用自制的催化剂和自行设计的高效催化反应器，成功地用催化加氢的方法，制备得到了13C-甲醇。
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| 关 键 词： | 13C标记 甲醇 催化加氢 |
Synthesis of 13C-labeled Methanol |
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| LUO Yong,DU Xiao-ning,SONG Jia-long,LU Ping-ye,LI Mei-hua.Synthesis of 13C-labeled Methanol[J].Isotopes,2012,25(4):214-218. |
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| Authors: | LUO Yong DU Xiao-ning SONG Jia-long LU Ping-ye LI Mei-hua |
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| Affiliation: | Shanghai Research Institute of Chemical Industry, Shanghai 200062, China |
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| Abstract: | A novel convenient method for the synthesis of 13C-methanol was described. 13C-methanol was prepared by means of catalytic hydrogenation, and then as synthesized methanol solution was further purified in a microscale high-efficient rectification column. The chemical purity of 13C-methanol was more than 99.5%. The synthetic route was featured by mild conditions and high yields of more than 90% based on isotopic substrate consumed. The product was characterized by GC-MS and 1H NMR, and the 13C abundance of 13C-methanol was more than 97%. Compared with the raw materials, the reduction of relative isotopic abundance of product was less than 1%. |
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| Keywords: | 13C-label methanol catalytic hydrogenation |
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