| D-半乳糖-1-13C的合成与表征 |
| |
| 引用本文： | 卢伟京,吴开成,李帅,徐仲杰.D-半乳糖-1-13C的合成与表征[J].同位素,2012,25(4):219-227. |
| |
| 作者姓名： | 卢伟京 吴开成 李帅 徐仲杰 |
| |
| 作者单位： | 上海化工研究院，上海200062 |
| |
| 基金项目： | 国家高技术研究发展计划项目(2008AA02Z427) |
| |
| 摘 要： | 以硝基甲烷13C为原料合成D-半乳糖-1-13C。采用分离中间体硝基糖醇的方式，简便拆分差向异构体D-半乳糖和D-塔罗糖，合成产物的总产率为42.6%，13C丰度为99.1%，光学纯度为100%，化学纯度为99.7%。以高效液相色谱 蒸发散射光检测器（HPLC-ELSD）、液相色谱-质谱联用仪（LC-MS）和核磁共振（1H NMR）对所得产物进行结构表征，确定产物结构为D-半乳糖-1-13C。
|
| 关 键 词： | D-半乳糖-1-13C 合成 13-C标记 |
Synthesis and Characterization of D-Galactose-1-13C |
| |
| LU Wei-jing,WU Kai-cheng,LI Shuai,XU Zhong-jie.Synthesis and Characterization of D-Galactose-1-13C[J].Isotopes,2012,25(4):219-227. |
| |
| Authors: | LU Wei-jing WU Kai-cheng LI Shuai XU Zhong-jie |
| |
| Affiliation: | Shanghai Research Institute of Chemical Industry， Shanghai 200062， China |
| |
| Abstract: | D-Galactose-1-13C was synthesized with nitromethane 13C as starting material. The separation was performed of the epimers of nitro D-Galactitol and nitro D-talitol, which resulted in D-Galactose being obtained and the resolution of the epimers of D-Galactose and D-taltose being avoidance. D-Galactose-1-13C was characterized by HPLC-ELSD, LC-MS and 1H NMR. The fine structure and 13C abundance of it were done by LC-MS and 1H NMR. The yield of 13C-labeled D-Galactose was 42.6% with 99.1% 13C abundance, 100.0% optical purity and 99.7% chemical purity. |
| |
| Keywords: | D-Galactose-1-13C synthesis 13C-labeled |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《同位素》浏览原始摘要信息 |
|
点击此处可从《同位素》下载全文 |
