| 稳定同位素15N标记水合肼的合成研究 |
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| 引用本文： | 王伟,杜晓宁,刘占峰,徐建飞.稳定同位素15N标记水合肼的合成研究[J].同位素,2012,25(4):204-209. |
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| 作者姓名： | 王伟 杜晓宁 刘占峰 徐建飞 |
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| 作者单位： | 上海化工研究院 上海稳定同位素工程技术研究中心，上海200062 |
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| 基金项目： | 科技部十二五支撑项目(2012BAK25B03-15);上海市科学技术委员会项目(上海化学试剂产业技术创新战略联盟:11DZ0511700) |
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| 摘 要： | 15N标记水合肼是稳定同位素标记化合物合成过程中一种常用的强还原剂，广泛应用于同位素标记药类化合物的合成。本研究通过单因素实验考察了15N标记水合肼合成过程中各因素对其收率的影响。结果表明，15N标记水合肼的最佳合成条件为：次氯酸钠的有效氯含量为115~120 g/L，氯化反应时间为30~40 min，水解回流时间为7 min，催化剂与尿素用量为m(催化剂) ∶m(尿素) =1.0∶10.0。在此条件下，水合肼合成收率达76.1%，丰度为99.20%。
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| 关 键 词： | 稳定同位素 15N标记 水合肼 |
Study on Synthesis of 15N-Hydrazine Hydrate |
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| WANG Wei,DU Xiao-ning,LIU Zhan-feng,XU Jian-fei.Study on Synthesis of 15N-Hydrazine Hydrate[J].Isotopes,2012,25(4):204-209. |
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| Authors: | WANG Wei DU Xiao-ning LIU Zhan-feng XU Jian-fei |
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| Affiliation: | Shanghai Engineering Research Center of Stable Isotope,Shanghai Research Institute of Chemical Industry, Shanghai 200062, China |
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| Abstract: | The 15N labeled hydrazine hydrate is a strong reducing agent in the synthesis procedure of stable isotope labeled compounds, and it has been widely used in the isotope-labeled pharmaceutical synthesis. The reaction conditions of 15N labeled hydrazine hydrate were mainly investigated by single-factor design, and the following optimized conditions were obtained: the concentration of available chlorine was 115-120 g/L, the chlorination reaction time was 30~40 min, the reflux time was 7 min, and the mass ratio of material was m(catalyst) ∶m(urea) =1.0∶10.0, and the yield of 15N labeled hydrazine hydrate was 76.1%, the abundance of 15N was 99.20%. |
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| Keywords: | stable isotope 15N labeled hydrazine hydrate |
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