| 聚山梨酯80/Fe3O4复合微球的制备、特性及在靶向MRI中的应用 |
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| 引用本文： | 叶燕斌,沈晓冬,崔升,仲阳,林本兰. 聚山梨酯80/Fe3O4复合微球的制备、特性及在靶向MRI中的应用[J]. 磁性材料及器件, 2011, 42(6): 57-62 |
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| 作者姓名： | 叶燕斌 沈晓冬 崔升 仲阳 林本兰 |
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| 作者单位： | 南京工业大学材料工程学院材料化学工程国家重点实验室,江苏南京,210009;东南大学附属南京江北人民医院,江苏南京,210048 |
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| 摘 要： | 采用化学共沉淀法制备出磁性纳米Fe3O4颗粒,以聚山梨酯80为改性剂制得聚山梨酯80/ Fe3O4复合微球.采用透射电镜( TEM)、X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FTIR)和振动样品磁强计( VSM)对其结构和性能进行了表征.结果表明:Fe3O4颗粒粒径在10～20nm,聚山梨酯80包覆在其表面.复合...
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| 关 键 词： | 聚山梨酯80/纳米Fe3O4复合微球 制备 特性 磁共振成像 造影剂 |
Preparation,properties of Fe3O4/Polysorbate-80 composite microspheres and their application in MRI |
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| YE Yan-bin,SHEN Xiao-dong,CUI Sheng,ZHONG Yang,LIN Ben-lan. Preparation,properties of Fe3O4/Polysorbate-80 composite microspheres and their application in MRI[J]. Journal of Magnetic Materials and Devices, 2011, 42(6): 57-62 |
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| Authors: | YE Yan-bin SHEN Xiao-dong CUI Sheng ZHONG Yang LIN Ben-lan |
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| Affiliation: | 1.College of Materials Science and Engineering,Nanjing University of Technology,Nanjing 210009,China; 2.Nanjing Jiangbei People’s Hospital,Nanjing 210048,China |
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| Abstract: | The magnetic Fe3O4 nanoparticles were prepared by co-precipitation method,then polysorbate-80 as modifier was coated on the surface of Fe3O4 nanoparticles to get Fe3O4/polysorbate-80 composite microspheres.The structure and properties of Fe3O4/polysorbate-80 composite microspheres were characterized by means of transmission electronmicroscope(TEM),X-ray diffraction(XRD),Fourier transform infrared spectrometry(FTIR) and vibrating sample magnetometer(VSM).The results showed that the diameter of Fe3O4 nanoparticle is 10~20 nm,polysorbate-80 is well coated on the surface of Fe3O4 nanoparticles.The saturation magnetization of the composite microspheres is 69.7 A?m2/kg.The composite microspheres show good dispersion and biocompatibility,and their injections as contrast agents are well applied in the MRI of brain-targeted to produce very good T2 imaging effect. |
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| Keywords: | Fe3O4/polysorbate-80 composite microspheres preparation properties MRI contrast agents |
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