| 阿奇霉素二水合物溶析结晶工艺优化 |
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| 引用本文： | 马博爱,龚俊波.阿奇霉素二水合物溶析结晶工艺优化[J].化学工业与工程,2015,32(1):37-40. |
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| 作者姓名： | 马博爱 龚俊波 |
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| 作者单位： | 1. 天津大学化工学院国家工业结晶工程技术研究中心, 天津 300072;
2. 天津大学现代药物传递及功能高效化天津市重点实验室, 天津 300072 |
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| 摘 要： | 针对阿奇霉素二水合物的溶析结晶工艺,考察了结晶的初始浓度、溶析剂流加速率以及搅拌强度对结晶产品的粒度分布的影响规律,确定了优化的工艺参数为结晶温度40 ℃,初始浓度0.32 g/g,搅拌速率为200 r/min,溶析剂滴加速率为200 μL/min。在此条件下可获得粒度分布约为300 μm到800 μm且主粒度约为580 μm的产品,克服目前结晶产品存在的聚结、粒度分布不均一等问题。
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| 关 键 词： | 阿奇霉素 溶析结晶 粒度分布 聚结 |
Optimization of Crystallization Process of Azithromycin Dihydrate |
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| Ma Boai
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Gong Junbo.Optimization of Crystallization Process of Azithromycin Dihydrate[J].Chemical Industry and Engineering,2015,32(1):37-40. |
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| Authors: | Ma Boai Gong Junbo |
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| Affiliation: | 1. The State Research Center of Industrialization for Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
2. Key Laboratory Modern Drug Delivery and High Efficiency, Tianjin University, Tianjin 300072, China |
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| Abstract: | In this paper, the influence of initial concentration, pumping rate of anti-solvent and agitation intensity on the crystal size distribution (CSD) of products was considered and then an optimized crystallization technology was proposed. The optimized products were obtained at 40 ℃ with 0.32 g/g initial concentration, 200 r/min agitation rate and 200 μL/min feeding rate. The CSD of products is from 300 μm to 800 μm and the mean crystal size is 580 μm. |
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| Keywords: | Azithromycin dilution crystallization crystal size distribution agglomeration |
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