A new enzymatically produced 1-lactulose: A pilot study to test the bifidogenic effects |
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Authors: | Karin Förster-Fromme Regina Schuster-Wolff-Bühring Annette Hartwig Aline Holder Andreas Schwiertz Stephan C Bischoff Jörg Hinrichs |
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Affiliation: | aInstitut für Ernährungsmedizin, Universität Hohenheim, Fruwirthstr. 12, 70599 Stuttgart, Germany;bInstitut für Lebensmittelwissenschaft und Biotechnologie, Universität Hohenheim, Garbenstr. 21, 70599 Stuttgart, Germany;cInstitut für Mikroökologie, Auf den Lüppen 8, 35745 Herborn, Germany |
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Abstract: | In a novel pilot plant scale process, lactulose was synthesized enzymatically, operating a maximum batch volume of 170 L. The test product was subjected to a randomized, double-blind, placebo-controlled pilot feeding study. Participants consumed a milk serum drink for 14 days, equalling a daily intake of about 3 g d−1 galactosyl-fructoses. Additionally, the effect of industrially produced lactulose and a placebo drink without lactulose was determined. So far, clinical studies on the prebiotic action of lactulose only focussed on the effects of industrially generated lactulose. The intake of enzymatically synthesized lactulose significantly increased (p = 0.001) faecal bifidobacterial counts, while there was no difference with industrially produced lactulose. Analysis of the compounds showed that the drink with enzymatically synthesized lactulose contained an additional disaccharide, β-1,1-galactosyl-fructose. Presumably, this sugar has a bifidogenic effect and may represent a novel prebiotic. |
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