Changes in nail keratin observed by Raman spectroscopy after Nd:YAG laser treatment |
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| Authors: | Min Kyung Shin Tae In Kim Wan Sun Kim Kyung Sook Kim |
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| Affiliation: | 1. Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea;2. Department of Biomedical Engineering, Graduate school, Kyung Hee University, Seoul, Korea;3. Program of Medical Engineering, Kyung Hee University, Seoul, KoreaHKP and KSK contributed equally to this work. |
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| Abstract: | Lasers and photodynamic therapy have been considered a convergence treatment for onychomycosis, which is a fungal infection on the nail bed and nail plate. Laser therapies have shown satisfactory results without significant complications for onychomycosis; however, the mechanism of clearing remains unknown. In this work, we investigated changes in the chemical structure of nail keratin induced by Nd:YAG laser using Raman spectroscopy. Toe nails with onychomycosis were treated with 1064 nm Nd:YAG laser. After laser treatment, the disulfide band (490–590 cm?1) of nail keratin was rarely observed or was reduced in intensity. The amide I band (1500–1700 cm?1) also showed changes induced by the laser. The α‐helical (1652 cm?1) structures dominated the β‐sheet (1673 cm?1) in nontreated nail, but the opposite phenomenon was observed after laser treatment. |
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| Keywords: | fungus keratin Nd:YAG onychomycosis Raman spectroscopy |
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