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| 三维全深度复频域光学相干层析成像系统及其对人体皮肤的在体成像 | |
| 引用本文： | 南楠,步鹏,郭昕,王向朝.三维全深度复频域光学相干层析成像系统及其对人体皮肤的在体成像[J].中国激光,2012,39(7):704002-125. |
| 作者姓名： | 南楠 步鹏 郭昕 王向朝 |
| 作者单位： | 南楠:中国科学院上海光学精密机械研究所信息光学与光电技术实验室， 上海 201800中国科学院研究生院， 北京 100049 步鹏:中国科学院上海光学精密机械研究所信息光学与光电技术实验室， 上海 201800 郭昕:中国科学院上海光学精密机械研究所信息光学与光电技术实验室， 上海 201800中国科学院研究生院， 北京 100049 王向朝:中国科学院上海光学精密机械研究所信息光学与光电技术实验室， 上海 201800中国科学院研究生院， 北京 100049 |
| 基金项目： | 国家自然科学基金(60938003，60878092)资助课题。 |
| 摘 要： | 基于正弦相位调制建立了用于人体皮肤在体三维成像的全深度复频域光学相干层析(FDOCT)成像系统。通过在不同横向位置获取的干涉谱信号中引入正弦相位调制,利用傅里叶变换结合带通滤波的方法重建复干涉谱信号,使成像深度范围扩大为原来的两倍,且适合对活体组织进行在体成像。通过优化相位调制周期内的采样点数,提高了镜像抑制比。基于该系统在体获得了人体皮肤的三维全深度层析图,图中角质层、表皮层及真皮乳突层等皮肤层状结构清晰可见,镜像消除比约为36dB。 |
| 关 键 词： | 成像系统 医疗与生物成像 光学相干层析 正弦相位调制 |
| 收稿时间： | 2012/3/9 |
Three-Dimensional Full-Range Complex Fourier Domain Optical Coherence Tomography System for Vivo Imaging of Human Skin |
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| Nan Nan,Bu Peng,Guo Xin,Wang Xiangzhao.Three-Dimensional Full-Range Complex Fourier Domain Optical Coherence Tomography System for Vivo Imaging of Human Skin[J].Chinese Journal of Lasers,2012,39(7):704002-125. | |
| Authors: | Nan Nan Bu Peng Guo Xin Wang Xiangzhao |
| Affiliation: | 1,2 1Laboratory of Information Optics and Opt-Electronic Technology,Shanghai Institute ofOptics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China 2Graduate University of Chinese Academy of Sciences,Beijing 100049,China |
| Abstract: | A three-dimensional (3D) full-range complex Fourier domain optical coherence tomography (FDOCT) system based on sinusoidal phase-modulating method is developed for vivo imaging of human skin. A complex spectral interferogram is retrieved based on Fourier transform analysis and bandpass filter of phase-modulated interference spectra, which is recorded with sinusoidal phase modulation introduced during lateral beam scanning. With the system, the depth imaging range is doubled and the signal-to-noise ratio degrading with the lateral scanning is avoided. Also the system is suitable for vivo imaging. 3D vivo full-range OCT images of human skin is achieved with the proposed system. In the images, the stratum corneum, the epidermis and the upper dermis can be clearly identified. By optimizing the sampling number in one modulation period, the complex conjugate rejection ratio is improved, which is about 36 dB. |
| Keywords: | imaging systems medical and biological imaging optical coherence tomography sinusoidal phase modulation |
| 本文献已被 CNKI 等数据库收录！ | |