| 生物法合成异丁酰胺的研究 |
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| 引用本文： | 高俊.生物法合成异丁酰胺的研究[J].现代化工,2012,32(6):59-60,62. |
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| 作者姓名： | 高俊 |
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| 作者单位： | 黑龙江省大庆炼化公司研究院,黑龙江大庆,163411 |
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| 摘 要： | 研究了生物法合成异丁酰胺的方法。采用腈水合酶催化异丁腈与水反应合成异丁酰胺,在20℃,发酵液体积分数为2.5%(v%)的条件下,获得最大反应速度为17.85714 mol(L.h),此时异丁腈的最大浓度约为0.18 mol/L。通过对反应液进行膜分离、精制和结晶,获得异丁酰胺的纯度大于99.9%,产品收率在98%以上。根据研究结果,生物法合成异丁酰胺具有产品收率高和纯度大的特点,适合生产高纯度异丁酰胺。
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| 关 键 词： | 异丁烯酰胺 异丁腈 腈水合酶 |
Study on biosythesis of isobutyramide |
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| GAO Jun.Study on biosythesis of isobutyramide[J].Modern Chemical Industry,2012,32(6):59-60,62. |
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| Authors: | GAO Jun |
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| Affiliation: | GAO Jun(Research Institute of Daqing Refining & Chemical Company,PetroChina,Daqing 163411,China) |
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| Abstract: | Isobutyramide is prepared by biosynthesis method in this study.The reaction of isobutyronitrile and H2O is catalyzed by nitrile hydratase.The maximum reaction rate(17.85714 mol/L·h) can be obtained under the following conditions:20℃ of the temperature,2.5%(v%) of the concentration of fermented liquid and about 0.18 mol/L of maximum concentration of isobutyronitrile.After membrane separation,purification and crystallization,the purity and the yield of isobutyramide are above 99.9% and above 98%,respectively.Based on this result,it indicates that the biosynthesis method is characterized by producing isobutyramide with high yield and high purity,which is suitable for the production of isobutyronitrile with high purity. |
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| Keywords: | isobutyramide isobutyronitrile nitrile hydratase |
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