Ringöffnung von 2-Oxocyclohexancarboxamid zu 2-Hydroximinopimelinsäure-1-amid

Ring Opening of 2-Oxocyclohexane Carboxamide to 2-Hydroximinopimelic-1-amide Reaction of 2-oxocyclohexane carboxamide ( 1 ) and sodium nitrite in 1n hydrochloric acid yields 2-hydroximinopimelic-1-amide ( 2 ). 2 and dimethylsulphate react to give compounds 3 and 4 , respectively, 2 and 1.6-diamino hexane form salt 5, 2 and cyclohexanone (resp. cyclopentanone) yield imidazoline-N-oxide 6 (and 7 , resp.) 2 and hydrazine afford pimelic hydrazide ( 8 ).