Consumption of c9,t11-18:2 or t10,c12-18:2 enriched dietary supplements does not influence milk macronutrients in healthy, lactating women |
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Authors: | Hasin Afroza Griinari J Mikko Williams Janet E Shahin Alam M McGuire Mark A McGuire Michelle K |
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Affiliation: | (1) Department of Food Science and Human Nutrition, Washington State University, Pullman, WA 99164-6376, USA;(2) Department of Animal Science, University of Helsinki, Helsinki, Finland;(3) Department of Animal and Veterinary Science, University of Idaho, Moscow, ID 83844-2330, USA;(4) Present address: Department of Animal and Veterinary Science, University of Idaho, Moscow, ID 83844-2330, USA;(5) Present address: Texas A & M University, College Station, TX 77843-2476, USA |
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Abstract: | Substantial research suggests that the t10,c12–18:2, but not the c9,t11–18:2, isomer of conjugated linoleic acid (CLA) reduces milk fat synthesis in lactating bovine and rodent species. Because
fat is the major energy-yielding component in human milk, we were interested in whether this is true for women as well. Thus,
the effects of c9,t11–18:2 and t10,c12–18:2 on milk fat were examined in breast-feeding women (n = 12) in a double-blind, placebo-controlled, crossover study with latin-square design. The study was divided into six periods:
baseline (3 days), three intervention periods (5 days each), and two washout periods (9 days each). During each intervention
period, women consumed 750 mg/day of a supplement containing predominantly c9,t11–18:2, t10,c12–18:2, or 18:1 (olive oil placebo). Milk was collected by complete breast expression on the final day of each period. Infant
milk consumption was estimated by 24 h weighing on the penultimate day of each intervention and washout period, and maternal
adiposity (% body fat) was determined at baseline using dual energy X-ray absorptiometry. Milk c9,t11–18:2 and t10,c12–18:2 concentrations were greater (P < 0.05) during the corresponding CLA treatment periods as compared to the placebo period, providing strong evidence of subject
compliance. Both CLA isomers were transferred into milk fat at relatively high efficiency; average transfer efficiency was
estimated to be 23.3%. Compared to the placebo treatment, milk fat content was not reduced during either CLA treatment. Data
indicate that body fatness did not modify any putative effect of isomeric CLA consumption on milk fat concentration. The evidence
from this study suggests that the sensitivity of lactating women’s mammary tissue to an anti-lipogenic effect of the t10,c12–18:2 isoform of CLA may be less than previously hypothesized. |
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Keywords: | Milk fat Lactation Human Conjugated linoleic acid CLA c9 t11– 18:2 t10 c12– 18:2 |
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