| 输血相关急性肺损伤的免疫机制 |
| |
| 引用本文： | 李锐,黄宇光.输血相关急性肺损伤的免疫机制[J].金属学报,2013,18(5):575-579. |
| |
| 作者姓名： | 李锐 黄宇光 |
| |
| 作者单位： | 中国医学科学院,北京协和医学院,北京协和医院麻醉科,北京 100730 |
| |
| 摘 要： | 输血相关急性肺损伤(TRALI)是接受任何血制品期间或 6 h 内新出现的急性肺损伤,是输血相关发病和死亡最常见的原因之一。基础和临床研究均表明血制品输注后免疫启动是肺损伤必需的步骤,抗原抗体反应触发一系列事件导致TRALI,主要涉及血制品人类白细胞抗原(HLA)和中性粒细胞抗原(HNA)抗体。TRALI重在预防,未来发病机制仍将是其研究重点。
|
| 关 键 词： | 输血相关急性肺损伤 免疫 人类白细胞抗原 人类中性粒细胞抗原 |
| 收稿时间： | 2012-06-12 |
| 修稿时间： | 2012-09-13 |
Immune mechanism of transfusion-related acute lung injury |
| |
| LI Rui,HUANG Yu-guang.Immune mechanism of transfusion-related acute lung injury[J].Acta Metallurgica Sinica,2013,18(5):575-579. |
| |
| Authors: | LI Rui HUANG Yu-guang |
| |
| Affiliation: | Department of Anesthesiology, Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China |
| |
| Abstract: | TRALI is one type of new-onset acute lung injury that happens within 6 h of initiation of any blood transfusion. It is one of the most common causes of transfusion-related morbidity and mortality. Both basic and clinical researches have demonstrated that immune priming is a fundamental step for lung injury. Antigen-antibody reactions trigger a series of events that lead to TRALI, which mainly relate to HLA and HNA antibodies of blood products. The prevetion is very important for TRALI and research on mechanism of TRALI will be still a key point. |
| |
| Keywords: | Transfusion-related acute lung injury Immunology Human lencocyte antigens Human neutrophit antigen |
|
| 点击此处可从《金属学报》浏览原始摘要信息 |
|
点击此处可从《金属学报》下载全文 |
|
