阿奇霉素对支气管哮喘患者肺功能及血清结缔组织生长因子的影响

目的: 观察阿奇霉素治疗支气管哮喘的临床疗效,及其对肺功能、血清结缔组织生长因子(Connective tissue growth factor,CTGF)的影响。方法: 48例哮喘患者随机分入常规治疗组(A组),阿奇霉素治疗组(B组);两组均吸入布地奈德,B组加服阿奇霉素,18名健康体检者做对照组(C组);ELISA法检测受试者血清中CTGF水平。评估治疗前后,各组患者哮喘控制测试评分、肺功能、血清CTGF的变化。结果: 治疗8周后,A、B两组患者的哮喘控制测试评分、肺功能指标均较治疗前有明显改善,血清中CTGF浓度亦明显下降,差异有统计学意义(P均<0.05);治疗8周后,B组哮喘控制测试评分、肺功能指标均明显高于A组,但血清CTGF浓度明显低于A组,差异有统计学意义(P均<0.05)。结论: 阿奇霉素可能通过抑制CTGF的表达,抑制气道重塑,改善肺功能,控制哮喘。

Effects of azithromycin on lung function and serum CTGF of asthma patients

AIM: To observe the clinical efficacy of azithromycin on bronchial asthma, and the effects on lung function, serum connective tissue growth factor (CTGF). METHODS: 48 cases of asthma were randomly divided into conventional treatment group (group A), azithromycin in treatment group (group B). Two groups were inhaled budesonide, group B was given azithromycin additional, 18 healthy people were distributed to control group (group C).The level of serum CTGF was detected by enzyme-linked immunosorbent assay (ELISA).The changes of asthma control test(ACT) scores,lung function, serum CTGF were evaluated in each group patients before and after treatment.RESULTS: After 8 weeks treatment, the levels of ACT scores, lung function were significantly improved than before treatment, but the serum CTGF concentrations were decreased in group A and B(all P<0.05). After 8 weeks treatment,compared with group A,the levels of ACT scores,lung function were significantly increased in group B, but the CTGF serum concentration was decreased(all P<0.05). CONCLUSION: Azithromycin can inhibit airway remodeling, improve lung function and control asthma,the reason may be related to inhibiting the expression of CTGF.