芝麻素对肾性高血压伴高血脂大鼠主动脉舒张功能的影响

目的: 探讨芝麻素(Sesamin,Ses)改善肾性高血压伴高血脂大鼠(Rrenal hypertensive-hyperlipidemia rat,RHHR)主动脉舒张功能损伤的作用机制。方法: RHHR灌服不同剂量Ses(100、33、10 mg·kg^-1·d^-1)8周后,测定主动脉环对乙酰胆碱(Acetylcholine,ACh)和硝普钠(Sodium nitroprusside,SNP)的舒张反应;测定一氧化氮合酶抑制剂左旋硝基精氨酸甲酯(N-nitro-L-arginine-methyl-ester,L-NAME)孵育后,动脉环对ACh的反应并计算一氧化氮(Nitric oxide,NO)活性。结果: 与假手术组相比,RHHR主动脉Ach和SNP诱导的舒张反应显著降低,NO活性减少,Ses治疗8周后能逆转上述作用。结论: Ses降压作用与改善RHHR主动脉内皮依赖性和非内皮依赖性舒张功能损伤有关。

Effects of sesamin on aortic relaxation in renal hypertensive-hyperlipidemia rats

AIM: To investigate the possible in vivo protective effects of sesamin on aortic relaxation in renal hypertensive-hyperlipidemia rats (RHHR).METHODS: RHHR were orally administrated with sesamin at a dose of 100, 33 and 10 mg·kg^-1·d^-1, respectively. After 8 weeks of treatment, the vasorelaxation response to acetylcholine (ACh) and sodium nitroprusside (SNP) was measured in aortic rings. Furthermore, the aortic response to ACh after being incubated with N-nitro-L-arginine-methyl-ester and NO bioactivity were determined.RESULTS: Compared with the sham-operated rats, ACh- and SNP- induced aortic vasorelaxation and NO bioactivity were obviously decreased in RHHR. These abnormalities were essentially reversed by treatment with sesamin for 8 weeks.CONCLUSION: All these results suggest that chronic treatment with sesamin reduces hypertension through improvement of impaired endothelium-dependent and -independent vasorelaxation in RHHR.