细辛脑注射液治疗小儿喘息性支气管炎临床疗效的Meta分析

目的: 评价细辛脑注射液治疗小儿喘息性支气管炎的有效性及安全性。方法: 检索2012年9月以前中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、维普期刊资源整合服务平台、万方数据库、中国生物医学文献数据库(CBM)、PubMed,收集有关细辛脑注射液用于小儿喘息性支气管炎治疗的临床研究进行Meta分析。结果: 纳入文献19篇,Meta分析结果显示,细辛脑组总有效率高于对照组,OR_合并=4.3,95%CI为(3.05,6.08),合并效应量的检验Z=8.3,P<0.01。其他次要结局指标如止咳天数、平喘天数、哮鸣音消失时间、胸片X线恢复正常时间、住院天数等均优于对照组,差异有统计学意义。安全性由于资料有限无法准确评价。结论: 细辛脑注射液能有效治疗小儿喘息性支气管炎,且效果优于对照组。

Meta-analysis: efficacy and safety of asarone on asthmatic bronchitis

AIM: To evaluate the efficacy and safety of asarone injection on asthmatic bronchitis. METHODS: The databases were retrieved from CNKI, VIP, CBM, PubMed,Chinese Technologic Journal Database (Weipu) and Wan Fang Digital Journal Full-text Database(before September 2012). The clinical researches about asarone injection in treating asthmatic bronchitis were collected to evaluate the clinical efficacy and safety by meta-analysis.RESULTS: 19 studies were included.The total effective rate of asarone group was higher than that of control group OR=4.3 and 95%CI =(3.05,6.08),Z=8.3,P<0.00001].And all of other secondary outcome measures of asarone group including cough days, asthma days, wheeze disappeared time, chest X-ray back to normal time, hospital days were better than those of control group, the difference was statistically significant. Safety of asarone injection could not be evaluated because of the information was limited.CONCLUSION: Asarone injection is effective in the treatment of asthmatic bronchitis.