联合应用间苯三酚与硫酸镁治疗急性胆绞痛的临床研究

目的: 观察联合应用间苯三酚与硫酸镁在治疗急性胆绞痛中的临床疗效以及不良反应情况。方法: 将本院肝胆外科2010年1月至2012年6月收治的300例胆绞痛患者随机分成间苯三酚组(A组)、间苯三酚+硫酸镁组(B组)、山莨菪碱组(C组),每组100例。结果: B组的有效率高于A组和C组(χ²=21.5000,P<0.01);A组有效率高于C组(χ²=6.6528, P<0.01)。B组的平均腹痛缓解时间少于C组(t=4.1067, P<0.01),B组的平均缓解时间与A组相似(t=0.7190,P=0.4730)。B组平均VAS分值低于A组和C组(F=285.6,P<0.01)。C组不良反应发生率高于A、B两组(χ²=115.6116,P<0.01)。A、B组之间不良反应发生率相似(χ²=0.0962,P=0.7564)。结论: 对于急性胆绞痛的治疗,联合使用间苯三酚与硫酸镁在症状改善、起效时间以及药物不良反应等方面明显优于单独使用间苯三酚或山莨菪碱,值得临床推广。

Combined use of Magnesium Sulfate and Benzene Three Phenol in the treatment of acute cholecystalgia

AIM: To analyze and evaluate the combined use of Benzene Three Phenol and Magnesium Sulfate in the treatment of acute cholecystalgia in the clinical efficacy and adverse reaction.METHODS: From January 2010 to June 2012,a total of 300 cases of patients were treated and randomly divided into A, B, C group. Group A were treated with Benzene Three Phenol, group B combined use of Benzene Three Phenol and Magnesium Sulfate treatment, group C by Anisodamine treatment with alkali.RESULTS: The efficiency of group B was higher than that in group C or group A(χ²=21.5000,P<0.01),the efficiency of group A was higher than that in group C(χ²=6.6528, P<0.01).Group B of the abdominal pain relief time was less than group C(t=4.1067, P<0.01),Group B of the abdominal pain relief time was similar to group A (t=0.7190,P=0.4730).Group B after administration of the VAS score lowest between group C and group A(F=285.6,P<0.01). Group C adverse reaction rate was higher than that of A and B (χ²=115.6116,P<0.01),and there was no significant difference between group B and group A(χ²=0.0962,P=0.7564).CONCLUSION: Combined use of Benzene Three Phenol and Magnesium Sulfate on acute cholecystalgia is more superiority in symptom,onset time and undesirable reaction,clinical curative effect is satisfactory, superior to use Benzene Three Phenol or anisodamine alone, worthy of clinical application.