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COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics |
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| Authors: | David F V Lewis |
| Affiliation: | David F V Lewis |
| Abstract: | An overview of the COMPACT method for evaluating potential toxicity mediated by cytochrome P450 enzymes is presented. Particular aspects of P450s are described, together with details of QSARs and homology modelling of mammalian P450s associated with foreign compound metabolism. © 2001 Society of Chemical Industry |
| Keywords: | cytochromes P450 COMPACT (computer ‐ optimized molecular parametric analysis of chemical toxicity QSAR (quantitative structure ‐ activity relationship) |