Insulin-like growth factor-I receptors in normal appearing white matter and chronic plaques in multiple sclerosis |
| |
Authors: | N Wilczak J De Keyser |
| |
Affiliation: | Department of Otolaryngology, Nara Medical University, Japan. |
| |
Abstract: | An in vivo microdialysis study using alpha-chloralose-anesthetized cats was performed to elucidate whether glutamate is actually released from the vestibular nerve terminals in the medial vestibular nucleus (MVN) with electrical stimulation of the vestibular nerve. When repetitive stimuli composed of rectangular pulses (200 micros in duration, 0.5 mA, and 0.1-50 Hz) were applied to the vestibular nerve for 10 min, a significant frequency-dependent increase in the release of glutamate was observed in the MVN. However, the levels of other amino acids such as aspartate, glycine and GABA remained unaltered with the stimuli. These findings indicate that glutamate is the primary afferent neurotransmitter from the vestibular nerve to the MVN neurons. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|