| Abstract: | Abstract Experimental results for the separation of S,R‐α‐Tetralol enantiomers obtained on preparative columns packed with particle size 20 µm of chiral adsorbent CHIRALPAK AD are presented. The total porosity was measured by using the non‐retained compound 1,3,5‐Tri‐tert‐butylbenzene and was 0.61. The permeability of the bed packed with CHIRALPAK AD was calculated as 4.4×10?13 m2. The efficiency of columns was characterized by the height equivalent to a theoretical plate (HETP) and a linear dependency has been found over tested flow rates. The HETP of S‐α‐Tetralol and R‐α‐Tetralol calculated at the flow rate 5.0 cm3/min were 320 µm and 340 µm, respectively. Thermodynamic adsorption parameters enthalpy, ΔH and entropy, ΔS, have been calculated from van't Hoff plot. Equilibrium and kinetics of adsorption of single enantiomers and racemic mixture of α‐Tetralol on CHIRALPAK AD were evaluated as well. The parameters for multicomponent isotherm linear‐Langmuir model are presented. The breakthrough curves of α‐Tetralol enantiomers are simulated with a mathematical model that accounts for axial dispersion and linear driving force for the intraparticle mass transfer. |
