Preparation and evaluation of metoprolol tartrate sustained-release pellets using hot melt extrusion combined with hot melt coating |
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Authors: | Yan Yang Lian Shen Juan Li |
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Affiliation: | School of Pharmacy, Zhejiang University of Technology, Hangzhou, China |
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Abstract: | The objective of this study was to prepare and evaluate metoprolol tartrate sustained-release pellets. Cores were prepared by hot melt extrusion and coated pellets were prepared by hot melt coating. Cores were found to exist in a single-phase state and drug in amorphous form. Plasticizers had a significant effect on torque and drug content, while release modifiers and coating level significantly affected the drug-release behavior. The mechanisms of drug release from cores and coated pellets were Fickian diffusion and diffusion–erosion. The coated pellets exhibited sustained-release properties in vitro and in vivo. |
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Keywords: | Metoprolol tartrate sustained-release pellets hot melt extrusion hot melt coating drug-release mechanism |
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