Degradation and miscibility of poly(DL-lactic acid)/poly(glycolic acid) composite films: Effect of poly(DL-lactic-co-glycolic acid) |
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| Authors: | ZHIGANG MA NA ZHAO CHENGDONG XIONG |
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| Affiliation: | 1. School of Chemical and Material Engineering, Huangshi Institute of Technology, Huangshi, 435003, P. R. China
2. Chengdu Organic Chemicals Co. Ltd., Chinese Academy of Sciences, Chengdu, 610041, P. R. China
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| Abstract: | The in vitro degradation behaviour of poly(glycolic acid) (PGA) and its composite films containing poly(DL-lactic acid) (PDLLA) and poly(DL-lactic-co-glycolic acid) (PDLGA) were investigated via mass loss, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). All the films were prepared by solution casting, using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the solvent. Since the degradation rate of PDLLA is lower than that of PGA, those of the PDLLA/PGA composite films decreased. As a compatibilizer, PDLGA improved the compatibility and hydrolytic stability of PDLLA/PGA composite films. Changes in the composite films indicate that this kind of PGA-based composite biomaterial may be applicable to device design for clinical application in the future. |
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