Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway |
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| Authors: | Xiaobo Li Hongbao Yang Shenshen Wu Qingtao Meng Hao Sun Runze Lu Jian Cui Yuxin Zheng Wen Chen Rong Zhang Michael Aschner Rui Chen |
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| Affiliation: | 1.Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health,Southeast University,Nanjing,China;2.Center for New Drug Safety Evaluation and Research,China Pharmaceutical University,Nanjing,China;3.School of Public Health, Qingdao University,Qingdao,China;4.Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Toxicology, School of Public Health,Sun Yat-sen University,Guangzhou,China;5.Department of Toxicology, School of Public Health,Hebei Medical University,Shijiazhuang,China;6.Department of Molecular Pharmacology,Albert Einstein College of Medicine,Bronx,USA;7.Institute for Chemical Carcinogenesis,Guangzhou Medical University,Guangzhou,China |
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| Abstract: | BackgroundInhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified.ResultsUsing whole-body dynamic inhalation model, we studied the interactions between aluminum oxide nanoparticles (Al2O3 NPs) and the pulmonary system in vivo. We found that seven-day-exposure to Al2O3 NPs resulted in emphysema and small airway remodeling in murine lungs, accompanied by enhanced inflammation and apoptosis. Al2O3 NPs exposure led to suppression of PTPN6 and phosphorylation of STAT3, culminating in increased expression of the apoptotic marker PDCD4. Rescue of PTPN6 expression or application of a STAT3 inhibitor, effectively protected murine lungs from inflammation and apoptosis, as well as, in part, from the induction of chronic obstructive pulmonary disease (COPD)-like effects.ConclusionIn summary, our studies show that inhibition of PTPN6 plays a critical role in Al2O3 NPs-induced COPD-like lesions. |
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