| 内标法测定养正消积胶囊中黄芪甲苷含量 |
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| 引用本文： | 王一波,张灿,李晓鹏,张永锋,李文烈,柏艳柳. 内标法测定养正消积胶囊中黄芪甲苷含量[J]. 食品与药品, 2022, 0(1): 56-59 |
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| 作者姓名： | 王一波 张灿 李晓鹏 张永锋 李文烈 柏艳柳 |
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| 作者单位： | 石家庄以岭药业股份有限公司;河北省中药炮制技术创新中心;络病研究与创新中药国家重点实验室;石家庄市复方中药技术创新中心 |
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| 摘 要： | 目的 提高养正消积胶囊的质量标准.方法 采用内标法建立高效液相-蒸发光散射法测定养正消积胶囊中黄芪甲苷的含量.色谱柱为Welch Ultimate XB-C18柱(250 mm×4.6 mm,5μm),流动相为乙腈-水(梯度洗脱),流速为1.0 ml/min,检测器为蒸发光散射检测器.结果 以木兰脂素为内标物,精密度试...
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| 关 键 词： | 养正消积胶囊 黄芪甲苷 内标法 高效液相-蒸发光散射法 |
Determination of Astragaloside IV in Yangzheng Xiaoji Capsules by Internal Standard Method |
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| WANG Yi-bo,ZHANG Can,LI Xiao-peng,ZHANG Yong-feng,LI Wen-lie,BAI Yan-liu. Determination of Astragaloside IV in Yangzheng Xiaoji Capsules by Internal Standard Method[J]. Food and Drug, 2022, 0(1): 56-59 |
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| Authors: | WANG Yi-bo ZHANG Can LI Xiao-peng ZHANG Yong-feng LI Wen-lie BAI Yan-liu |
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| Affiliation: | (Shijiazhuang Yiling Pharmaceutical Co.,Ltd.,Shijiazhuang 050035,China;Hebei Provincal Technology Innovation Center of Chinese Medicinal Herbs Preparation,Shijiazhuang 050035,China;National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine,Shijiazhuang 050035,China;Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center,Shijiazhuang 050035,China) |
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| Abstract: | Objective To improve the quality standard of Yangzheng Xiaoji Capsules.Methods The content of astragaloside IV in Yangzheng Xiaoji Capsules was determined by HPLC-ELSD with internal standard method.The separation was carried out on a Welch Ultimate XB-C18 column(250 mm×4.6 mm,5μm)with the mobile phase consisting of acetonitrile-water by gradient elution.The flow rate was 1.0 ml/min and the detector was evaporative light-scattering detector.Results Magnolin was chosen as the internal standard material with RSD of 0.18%.The average recovery rate was 98.99%with RSD of 2.78%(n=9).Conclusion The method is accurate,stable,reproducible,and can be used for the determination of astragaloside IV in Yangzheng Xiaoji Capsules. |
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| Keywords: | Yangzheng Xiaoji Capsules astragaloside IV internal standard method HPLC-ELSD |
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