Pulsed cold plasma-induced blood coagulation and its pilot application in stanching bleeding during rat hepatectomy |
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| Affiliation: | 1. Institute of Industrial Ecology and Environment, Zhejiang University, Hangzhou 310007, People's Republic of China;2. Zhejiang Center for Medical Device Adverse Events Monitoring and Safety Research, Hangzhou 310009,People's Republic of China;3. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, People's Republic of China |
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| Abstract: | This paper presents plasma-induced blood coagulation and its pilot application in rat hepatectomy by using a home-made pulsed cold plasma jet.Experiments were conducted on blood coagulation in vitro,the influence of plasma on tissue in vivo,and the pilot application of rat hepatectomy.Experimental results show that the cold plasma can lead to rapid blood coagulation.Compared with the control sample,the plasma-induced agglomerated layer of blood is thicker and denser,and is mostly composed of broken platelets.When the surface of the liver was treated by plasma,the influence of the plasma can penetrate into the liver to a depth of about 500 μm.During the rat hepatectomy,cold plasma was proved to be effective for stanching bleeding on incision.No obvious bleeding was found in the abdominal cavities of all six rats 48 h after the hepatectomy.This implies that cold plasma can be an effective modality to control bleeding during surgical operation. |
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| Keywords: | cold plasma jet blood coagulation stanching bleeding hepatectomy plasma medicine |
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