Maternal Intake of Fish Oil but not of Linseed Oil Reduces the Antibody Response in Neonatal Mice |
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Authors: | Lotte Lauritzen T M R Kjær T Porsgaard M B Fruekilde H Mu H Frøkiær |
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Affiliation: | (1) Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark;(2) Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark;(3) Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark;(4) Department of Basic Sciences and Environment, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark |
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Abstract: | Dietary levels of n-3 PUFA are believed to influence the immune system. The importance of the source of n-3 PUFA is debated.
This study addressed how the content and source of n-3 PUFA in the maternal diet influenced tissue FA composition and the
immune response to ovalbumin (OVA) in mice pups. From the day of conception and throughout lactation, dams were fed diets
containing 4% fat from linseed oil (LSO), fish oil (FO) or a n-3 PUFA-deficient diet (DEF). Pups were injected with OVA within
24 h of birth and sacrificed at weaning (day 21). Overall, the content of n-3 PUFA in milk, liver and spleen reflected the
source and only minor differences were observed in brain phospholipid 22:6n-3. The source had only limited influence on the
n-3 PUFA accretion in peripheral tissue, with most pronounced differences in the spleen. The marine PUFA-group had reduced
levels of total OVA-specific antibodies and OVA-IgG1 titers in the pup blood, while the response in the LSO-group did not
differ from that in the DEF-group. There were no statistical differences in the cytokine responses to OVA-stimulated splenocytes,
but the decrease in IgG1 was paralleled by an increase in IFNγ-production and a decrease in IL-6-production. Our results indicate
that maternal intake of FO, but not of LSO, changes the offspring’s antigen-specific response and potentially increases Th1-polarization. |
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