A sample-and-hold current measurement integrated circuit for neural recording

This paper describes a new differential sample-and-hold technique of current measurement for neural probing. The design utilizes bottom plate sampling (BPS) and T-transmission switches to mitigate signal coupling and a differential sample-and-hold technique to reduce charge injection and clock feed through. The circuit was fabricated in a 0.35?µm CMOS process and tested using different input loads to model the electrochemical properties of the microelectrode. Test results matched closely with the simulation results, proving that the concept of the sample-and-hold current measurement circuit is valid for neural probing.