Reduction of postsurgical adhesion formation with CM‐chitosan hydrogel barriers prepared by using γ‐irradiation |
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| Authors: | Hui‐Jeong Gwon Youn‐Mook Lim Ho‐Nam Chang Young‐Chang Nho |
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| Affiliation: | 1. Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup‐si, Jeonbuk 580‐185, Korea;2. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejon 305‐701, Republic of Korea;3. Radiation Research Division for Industry and Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup‐si, Jeonbuk 580‐185, Korea?Y.‐C. Nho is a major contributor for this work. |
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| Abstract: | To evaluate the efficiency of carboxymethylchitosan (CM‐chitosan)‐based hydrogels as barriers for reducing postsurgical adhesions, CM‐chitosan was synthesized to simplify the hydrogel‐making process, and the CM‐chitosan solutions were cross‐linked by using γ‐ray irradiation to create the desired hydrogels instead of using chemical cross‐linking reagents. The prepared CM‐chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel‐fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation‐induced CM‐chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 |
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| Keywords: | adhesion cross‐linking gels irradiation swelling |
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