Potentiometric determination of ketoprofen and piroxicam at a new PVC electrode based on ion associates of Rhodamine 6G |
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| Authors: | Zholt Kormosh Iryna Hunka Yaroslav Bazel Oksana Matviychuk |
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| Affiliation: | 1. Department of Analytical Chemistry, Volyn National University, Voli av., 13, 43021 Lutsk, Ukraine;2. Department of Analytical Chemistry, Uzhgorod National University, Pidgirna st., 46, 88000 Uzhgorod, Ukraine;3. Department of Analytical Chemistry, P.J. Safarik University, Moyzesova st., 11, 04154 Kosice, Slovakia |
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| Abstract: | The characteristics, performance and application of ion-selective electrodes for ketoprofen and piroxicam ions based on Rhodamine 6G as electrode-active substances are described. These electrodes respond with sensitivities of (58.0 ± 1.0) and (57.0 ± 2.0) mV/decade over the range 1.0 × 10? 4–1.0 × 10? 1 and 1.0 × 10? 4–5.0 × 10? 2 mol/l at pH 5–9 and 6–10 and a detection limit of 6.3 × 10? 5 and 3.2 × 10? 5 mol/l for ketoprofen and piroxicam, respectively. The electrodes are easily constructed at a relatively low cost, have a fast response time and can be used for a period of 5 months without any considerable divergence in potential. The proposed sensor displayed good selectivity for ketoprofen and piroxicam in the presence of several substances and inorganic anions. It was used for the direct assay of ketoprofen and piroxicam in commercial pharmaceutical preparations. |
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