Risk assessment of airborne fine particles and nanoparticles |
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Authors: | Toshihiko Myojo Akira Ogami Takako Oyabu Yasuo Morimoto Masami Hirohashi Masahiro Murakami Kenichiro Nishi Chikara Kadoya Isamu Tanaka |
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Affiliation: | University of Occupational and Environmental Health, Institute of Industrial Ecological Sciences, Japan |
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Abstract: | Pulmonary health effects of fine particles and nanoparticles are overviewed in this paper, mainly based on the researches conducting in our laboratory. For the hazard assessment, we exposed rats to aerosolized asbestos-substitutes or nanoparticles aerosols (nickel oxide and titanium dioxide), and examined the biological and pathological effects of the particle on lung, a major target organ for the particles, and cytokines which are related to inflammation, fibrosis and carcinogenesis in the lung. It is essential to perform comprehensive evaluation of the toxicity of poorly soluble powder samples using the precise characterization data and exposure methods, such as single instillation or aerosol inhalation. |
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