Using hydrophilic polysaccharide to modify supramolecular hydrogel from a low-molecular-mass gelator |
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Authors: | Fei Song Li-Ming Zhang Jun-Feng Shi Nan-Nan Li Chuan Yang Li Yan |
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Affiliation: | 1. Key Laboratory for Designed Synthesis and Application of Polymer Materials, School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China;2. Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China;3. Second Affiliated Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou 510102, China |
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Abstract: | Small molecular hydrogels hold important potential applications in bioengineering and biomedicine. However, they suffer usually from weak mechanical and water-retention properties. In this work, hydrophilic dextran polysaccharide was used for the first time to modify the properties of the supramolecular hydrogel derived from a low-molecular-mass gelator, 2, 6-di[N-(carboxyethyl carbonyl)amino]pyridine (DAP). When the DAP hydrogel was formed in aqueous dextran solution with a rather low viscosity, we found that it could be significantly reinforced with respect to its viscoelastic moduli, complex viscosity and hydrogel strength. Moreover, the modified DAP hydrogel has a higher bound water content. These property changes could be attributed to the formation of intermolecular hydrogen bonds between DAP and dextran. By relating the dynamic rheological data with a scaling model, it was found that native and modified DAP hydrogels had both a fractal aggregate structure and the incorporation of dextran resulted in an increase of the fractal dimension. Scanning electron microscopy revealed that a more complex network structure was formed in the DAP hydrogel with dextran. |
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