| Comparative and optimized studies on radiosynthesis of O-（2-[^18F]fluoroethyl）-L-tyrosine |
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| 作者姓名： | WANG Ming-Wei YIN Duan-Zhi WANG Yong-Xian CHENG Deng-Feng LI Gu-Cai ZHOU Wei |
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| 作者单位： | Radiopharmaceutical Centre, Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800 |
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| 基金项目： | Supported by the Knowledge Innovation Project of Chinese Academy of Sciences （No.KJCX-SW-08） and the National Natural Science Foundation of China （No.30371634） |
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| 摘 要： | O-（2-^18F]fluoroethyl）_L-tyrosine （^18F]FET）, one of radiolabelled amino acids, is a very promising brain tumor positron emission tomography （PET） imaging agent and holds clinical potential. This paper described out a comparative and optimized radiosynthesis of ^18F]FET, concerning three aspects of its two-step preparation method, including reaction components, heating methods and reaction models. As a result, good radiochemical yield （about 45%, no-decay-corrected） and radiochemical purity （more than 95%） were achieved, and total synthesis time of ^18F]FET was shortened within 20 min and radiation exposure time also decreased.
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| 关 键 词： | 酪氨酸 放射合成 衍生物 氨基酸 |
| 收稿时间： | 2005-03-15 |
Comparative and optimized studies on radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine |
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| WANG Ming-Wei YIN Duan-Zhi WANG Yong-Xian CHENG Deng-Feng LI Gu-Cai ZHOU Wei.Comparative and optimized studies on radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine[J].Nuclear Science and Techniques,2005,16(5):283-288. |
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| Authors: | WANG;Ming-Wei;YIN;Duan-Zhi;WANG;Yong-Xian;CHENG;Deng-Feng;LI;Gu-Cai;ZHOU;Wei |
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| Abstract: | O-(2-18F]fluoroethyl)-L-tyrosine (18F]FET), one of radiolabelled amino acids, is a very promising brain tumor positron emission tomography (PET) imaging agent and holds clinical potential. This paper described out a comparative and optimized radiosynthesis of 18F]FET, concerning three aspects of its two-step preparation method, including reaction components, heating methods and reaction models. As a result, good radiochemical yield (about 45%, no-decay-corrected) and radiochemical purity (more than 95%) were achieved, and total synthesis time of 18F]FET was shortened within 20 min and radiation exposure time also decreased. |
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| Keywords: | ^18F L-tyrosine Radiosynthesis Positron emission tomography |
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