| pH响应两亲性壳聚糖衍生物的合成与表征 |
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| 引用本文： | 于妙卓,;费学宁,;张宝莲,;李旭坤,;茈梦雨. pH响应两亲性壳聚糖衍生物的合成与表征[J]. 天津城市建设学院学报, 2014, 0(3): 190-193 |
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| 作者姓名： | 于妙卓, 费学宁, 张宝莲, 李旭坤, 茈梦雨 |
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| 作者单位： | [1]天津城建大学材料科学与工程学院,天津300384; [2]天津城建大学理学院,天津300384 |
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| 基金项目： | 国家自然科学基金（51178289）;教育部科学技术研究重点项目（211005） |
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| 摘 要： | 以天然可生物降解高分子壳聚糖为原料，通过在壳聚糖氨基上引入辛基作为疏水基，在羟基上引入琥珀酸酐作为亲水基，形成具有两亲性的壳聚糖．通过红外、紫外和差热法对最终产物进行了表征，证实疏水基团和亲水基团成功引入壳聚糖．芘荧光探针法测定产物，胁界胶束质量浓（CMC）为0．072mg／mL．双亲修饰的壳聚糖可在水中形成胶柬且具有pH敏感性．紫外透光率和粒径联合评价其pH响应范围为4．55．5．
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| 关 键 词： | 壳聚糖 两亲性 pH响应 胶束 |
Synthesis and Characterization of pH-Response Amphiphilic Chitosan Derivatives |
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| Affiliation: | YU Miao-zhuo, FEI Xue-ning, ZHANG Bao-lian, LI Xu-kun, ZI Meng-yu ( School of Materials Science and Engineering; School of Science, Tianjin Chengjian University, Tianjin 300384, China) |
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| Abstract: | An amphipathic chitosan was synthesized using hydrophobic and hydrophilic chitosans prepared by grafting octyl and carboxyl benzoyl groups onto the natural biodegradable polymer chitosan. The chemical structure of galactosylated chitosan was characterized by FTIR, UVS, DSC, and proved the successful grafting of hydrophobic group and hydrophilic group onto the chitosan. The CMC of the chitosan derivatives was determinated to be 0.072mg/mL by Pyrene fluorescence probe method. The pH sensitivity of the pH-sensitive chitosan was evaluated by the ultraviolet-infrared spectrometer and particle size instrument, and the results showed that the range of the pH-sensitivity was 4.5-5.5. |
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| Keywords: | chitosan amphipathic pH-response micell |
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