| 熔融法合成(S)-1-苄基-3羟基吡咯烷-2,5-二酮 |
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| 引用本文： | 魏林,陆晨熠,邱飞.熔融法合成(S)-1-苄基-3羟基吡咯烷-2,5-二酮[J].精细化工中间体,2011,41(1):27-28,34. |
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| 作者姓名： | 魏林 陆晨熠 邱飞 |
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| 作者单位： | 华侨大学分子药物学研究所,福建泉州,362021;分子药物教育部工程研究中心,福建泉州,362021 |
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| 基金项目： | 基金项目：福建省自然科学基金（2009J05029）资助项目,福建省生物医药工程研究生教育创新基地资助项目（06070205）,华侨大学科研基金（08BS412）资助项目. |
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| 摘 要： | 以L-苹果酸为原料,与苄胺反应,再经熔融法得到标题化合物。考察了反应温度和时间对反应收率的影响,优化条件为:反应温度140℃,反应时间8 h,标题化合物的收率为68%。目标化合物结构经核磁共振氢谱、红外、比旋度确证。
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| 关 键 词： | (S)-1-苄基-3-羟基吡咯烷-2 5-二酮 熔融反应 绿色合成 |
Melting Reaction for Synthesis of (S)-1-Benzyl-3-hydroxypyrrolidine-2,5-dione |
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| WEI Lin,LU Chen-yi,QIU Fei.Melting Reaction for Synthesis of (S)-1-Benzyl-3-hydroxypyrrolidine-2,5-dione[J].Fine Chemical Intermediates,2011,41(1):27-28,34. |
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| Authors: | WEI Lin LU Chen-yi QIU Fei |
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| Affiliation: | (Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China; Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021, China) |
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| Abstract: | 1-Benzyl-3-hydroxypyrrolidine-2,5-dione could be synthesized via melting reaction of the salt formed by L-malic acid and benzylamine in methanol. The reaction was carried out at different temperatures and times. We found that the best conditions were 140℃ and 8h with the yield of 68%. The structure of the target product was confirmed by 1H NMR, IR and specific rotation. |
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| Keywords: | （S）-1-benzyl-3-hydroxypyrrolidine-2 5-dione melting reaction green synthesis |
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