| 1-甲基-1,2,3,4-四氢异喹啉的合成工艺改进 |
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| 引用本文： | 何学仙,万银波,李颖,宋宏锐. 1-甲基-1,2,3,4-四氢异喹啉的合成工艺改进[J]. 精细化工中间体, 2011, 41(1): 35-36,56 |
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| 作者姓名： | 何学仙 万银波 李颖 宋宏锐 |
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| 作者单位： | 沈阳药科大学制药工程学院,辽宁沈阳,110016 |
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| 摘 要： | 以苯乙胺为原料,经乙酰化反应得乙酰苯乙胺(3),在甲基磺酸的作用下环合得1-甲基-3,4-二氢异喹啉(4),经硼氢化钠还原得1-甲基-1,2,3,4-四氢异喹啉(1)。改进了合成工艺,总收率达80.8%。
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| 关 键 词： | 1-甲基-1,2,3,4-四氢异喹啉 甲基磺酸 工艺改进 |
Improvement on the Synthesis of 1-Methyl-1,2,3,4-tetrahydroisoquinoline |
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| HE Xue-xian,WAN Yin-bo,LIN Ying,SONG Hong-rui. Improvement on the Synthesis of 1-Methyl-1,2,3,4-tetrahydroisoquinoline[J]. Fine Chemical Intermediates, 2011, 41(1): 35-36,56 |
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| Authors: | HE Xue-xian WAN Yin-bo LIN Ying SONG Hong-rui |
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| Affiliation: | (School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | 1-Methyl-1,2,3,4-tetrahydroisoquinoline(1) was prepared from phenylethylamine via acetylation with acetyl chloride,cyclization with methanesulfonic acid and reduction with sodium borohydride.The synthetic process was improved and the overall yield was 80.8%. |
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| Keywords: | 1-methyl-1,2,3,4-tetrahydroisoquinoline methanesulfonic acid process improvement |
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