以b-环糊精、2-羟丙基-b-环糊精和4-乙烯吡啶为功能单体制备氟比洛芬分子印迹聚合物及其吸附特征

以b-环糊精(β-CD)、2-羟丙基-β-环糊精(HP-β-CD)和4-乙烯吡啶(4-VP)为功能单体，以氟比洛芬为模板分子，以环氧氯丙烷和乙二醇二甲基丙烯酸酯为交联剂，采用本体聚合法制备分子印迹聚合物(MIPs)，对氟比洛芬与功能单体的相互作用和MIPs的结构进行了表征，比较了3种MIPs对氟比洛芬的吸附性能. 结果表明，β-CD, HP-β-CD和4-VP与氟比洛芬之间以较强的相互作用形成复合物，通过交联、聚合形成聚合物，以HP-β-CD作功能单体所得聚合物印迹效果最佳，具有较强的特异性吸附能力，印迹因子和特异性吸附率分别为1.79和38.92%，分子印迹机制是β-CD的锥筒包结作用和羟丙基的亲和作用形成印迹空穴.

Preparation of Molecularly Imprinted Polymers for Flurbiprofen with b-Cyclodextrin, 2-Hydroxypropyl-b-Cyclodextrin and 4-Vinyl Pyridine as Functional Monomers and Their Adsorption Property

Using b-cyclodextrin (β-CD), 2-hydroxypropyl-b-Cyclodextrin (HP-b-CD) and 4-vinyl pyridine (4-VP) as functional monomers, the molecular imprinted polymers (MIPs) for flurbiprofen were synthesized by bulk polymerization, and their prepolymerization was characterized. MIPs were scanned by FT-IR for their chemical structure, and tested by static absorption for their adsorption properties. The results showed that b-CD, HP-β-CD and 4-VP had a certain interaction with flurbiprofen, their adsorption rate to flurbiprofen was more than 86.80%, but the MIP formed by HP-β-CD as functional monomer indicated better adsorption specificity for flurbiprofen with the imprinted factor 1.79 and specific adsorption rate 38.92%. Its specificity depended on the inclusion of cones and the affinity of 2-hydroxypropyl groups on HP-β-CD molecules.